委内瑞拉移民中移民后感染SARS-CoV-2:一种基于实验室的流行病学观察研究
Edmilson F de Oliveira-Filho1, Ruth A Martínez-Vega2, Andres Moreira-Soto1
1Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Virology, Berlin, Germany.
Travel medicine and infectious disease
|October 18, 2024
概括
委内瑞拉移民的SARS-CoV-2 IgG血清流行率为34.2%,感染主要发生在抵达哥伦比亚后. 改善基础设施对于防止传染病在移民人口中传播至关重要.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 传染性疾病 传染性疾病
背景情况:
- 自2015年以来,超过600万委内瑞拉人移民到哥伦比亚和邻国.
- 移民在COVID-19大流行期间继续旅行,尽管采取了封锁措施.
研究的目的:
- 调查到达哥伦比亚的委内瑞拉移民中SARS-CoV-2感染的流行率和特征.
- 为了确定先前存在的抗体是否影响了感染或症状的发展.
- 为了确定主要的SARS-CoV-2变种及其在这个人群中的起源.
主要方法:
- 在哥伦比亚布卡拉曼加抵达后采访了1209名委内瑞拉成年移民 (2021年4月至9月).
- 收集社会经济,临床数据,血液和唾液样本.
- 使用血清学,分子学 (RT-PCR) 和遗传学工具评估SARS-CoV-2感染.
主要成果:
- 在SARS-CoV-2的RT-PCR阳性为1.9%;血清流行率 (IgG) 为34.2%.
- 感染与哥伦比亚逗留超过14天有显著的关联 (流行率3.3).
- 与感染者接触相关的SARS-CoV-2变种 (Mu,Gamma) 和抗体检测表明移民后感染.
结论:
- SARS-CoV-2感染主要发生在迁移后,可能是由于拥挤的边境营地.
- 加强基础设施和医疗保健对于制COVID-19和其他传染病的移民相关传播至关重要.
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