在中国西北地区对常见花粉过敏原的交叉反应概况,基于组件解决诊断
Aoli Li1, Zhifeng Huang1, Qingyuan Ye1
1Department of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, No. 28 Qiaozhong road, Liwan district, Guangzhou (Canton), 510120, China.
Scientific reports
|October 18, 2024
概括
像Art v,Phl p和Bet v这样的花粉过敏症正在增加. 这项研究发现,林蛋白 (Phl p 12, Bet v 2) 引起交叉反应,导致呼吸道过敏患者共享敏感.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏学 过敏学
- 环境健康 环境健康
背景情况:
- 全球过敏性鼻炎和喘患病率的增加.
- 花粉过敏是一个主要的敏感化因素.
- 不同的花粉过敏之间的不清楚交叉反应使诊断和治疗复杂化.
研究的目的:
- 研究Art v,Phl p和Bet v花粉过敏原之间的交叉反应性.
- 确定负责交叉反应的特定过敏原成分.
- 了解呼吸道过敏患者的敏感化机制.
主要方法:
- 组件解决诊断 (CRD) 用于测量针对52名患者的特定IgE.
- 对Art v,Phl p,Bet v,Amb a,Amb p及其组件进行IgE测试.
- 使用Art v,Phl p和Bet v提取物进行了sIgE抑制试验.
主要成果:
- 艺术v1是艺术v过敏的主要组成部分 (64.6%).
- 在Phl p 12 (75.0%) 和Bet v 2 (75.6%) 的Phl p和Bet v过敏中,分别存在很高的患病率.
- 亚特v,Phlp和Betv提取物显示出显著的交叉反应性,特别是涉及Phlp12和Betv2.
结论:
- 第1条是第5条的主要过敏原.
- 个人蛋白蛋白 (Phl p 12, Bet v 2) 是呼吸道过敏中关键的交叉反应元素.
- 在Art v,Phlp和Bet v之间交叉反应表明了共享的敏感化机制.
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