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Updated: May 5, 2026

Investigation of Genetic Dependencies Using CRISPR-Cas9-based Competition Assays
11:05

Investigation of Genetic Dependencies Using CRISPR-Cas9-based Competition Assays

Published on: January 7, 2019

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基因型从表型:使用CRISPR屏幕剖析淋巴瘤生物学

Arnold Bolomsky1, Jaewoo Choi1, James D Phelan2

  • 1Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Methods in molecular biology (Clifton, N.J.)
|October 18, 2024
PubMed
概括

这项研究详细介绍了人类淋巴瘤细胞中CRISPR-Cas9查的协议,以了解基因功能. 这些方法可以有效地对细胞表型进行基因查.

关键词:
克里斯普尔-Cas9是什么意思DLBCL DLBCL 是一个字母.功能性基因组学是一种功能性基因组学.高通量屏幕的高通量屏幕.淋巴瘤是一种淋巴瘤.克里斯普尔是什么意思?克里斯普尔是什么意思?

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Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
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