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在ER出口站点的TDP43聚合损害了ER到Golgi的运输

Hongyi Wu1, Loo Chien Wang2, Belle M Sow1

  • 1Mechanobiology Institute, National University of Singapore (NUS), Singapore, Singapore.

Nature communications
|October 18, 2024
PubMed
概括

人体细胞中的蛋白质聚合形成了多样化的包容. 一种关键的蛋白质,TDP43,聚合在肌缩侧面硬化症 (ALS) 的ER出口部位,破坏细胞运输.

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