在帕金森病中,伸手和踏步对药物和暗示有不同的反应
Allen Hill1, Hiram Cantú2,3,4,5, Julie N Côté2,4,5
1School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada.
Scientific reports
|October 18, 2024
概括
帕金森病 (PD) 患者在多关节运动中表现出时间差异,药物影响节奏. 听觉线索可以提高PD患者和健康个体的计时精度.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 时间生物学 时间生物学
背景情况:
- 基底腺节对于内部计时至关重要.
- 多巴胺类药物可以改善在单关节运动期间帕金森病 (PD) 的时间缺陷.
- 多巴胺类药物和听觉线索对PD多关节运动时间的影响尚不清楚.
研究的目的:
- 调查多巴胺激素药物和听觉线索对PD患者多关节运动中的时间表现的影响.
- 为了比较PD患者的时间缺陷与健康对照者在达到和步进任务时.
主要方法:
- 25名患有PD的个人 (测量启动和关闭药物) 和12名健康对照进行了重复的伸手和站立任务.
- 参与者以他们自己选择的最大节奏执行了带有或没有听觉线索的任务.
- 使用Wing-Kristofferson模型分析了时间变化,时钟差异,电机差异和串行滞后-1相关性.
主要成果:
- 两组都显示了减少的节奏错误与听觉线索.
- 与OFF药物相比,服用PD ON药物的个人表现出较低的节奏.
- 虽然整体时间变化没有差异,但时钟和运动差异估计显示了群体和任务特定的差异.
- 一种药物和暗示的相互作用增加了在达到时的时钟变异,在未治疗的,ON PD个体.
- 步行期间PD患者的时钟和运动变异不受线索的影响,与对照组不同.
结论:
- 总体时间变化可能无法完全捕捉帕金森病的时间缺陷.
- 多巴胺类药物和听觉线索对PD多关节运动的时间控制有不同的影响.
- 特定任务的时间缺陷及其通过药物和线索的调节需要在PD进行进一步的研究.
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