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线粒体长非编码RNA lncMtloop调节线粒体转录,并抑制阿尔茨海默病的发生

Wandi Xiong1,2,3, Kaiyu Xu4, Jacquelyne Ka-Li Sun5

  • 1Peking-Tsinghua Center for Life Sciences, Beijing, China.

The EMBO journal
|October 18, 2024
PubMed
概括

一种新的线粒体非编码RNA,IncMtDloop,对于维护线粒体功能至关重要,并且在阿尔茨海默病 (AD) 中降低. 在AD小鼠中恢复IncMtDloop水平改善了线粒体健康,并减少了类似AD的症状.

关键词:
在IncMtDloop中使用.阿尔茨海默氏症是阿尔茨海默氏症的疾病.线粒体恒常化是线粒体的恒常化.在TFAM中,我们可以使用TFAM.我们的mtDNA mtDNA

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