在3,137名男性中进行口腔人类乳头瘤病毒发病率的多国流行病学分析
Racheal S Dube Mandishora1, Brittney L Dickey2, Wenyi Fan3
1Center for Immunization and Infection Research in Cancer, Moffitt Cancer Center, Tampa, FL, USA.
Nature microbiology
|October 18, 2024
概括
男人有风险在他们的一生中获得口腔人类乳头瘤病毒 (HPV) 感染. 补时接种疫苗可以帮助减少新的口腔HPV感染,并预防口腔癌 (OPC).
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 口腔人类乳头瘤病毒 (HPV) 感染是口腔癌 (OPC) 的已知危险因素.
- 全球OPC发病率正在上升,但关于口腔HPV感染患病率的数据仍然很少.
- 了解口腔HPV流行病学对于公共卫生干预至关重要.
研究的目的:
- 分析男性口腔HPV感染的发病率和危险因素.
- 评估男性人口中获得口腔HPV的长期风险.
- 为潜在的疫苗接种策略提供信息,以预防OPC.
主要方法:
- 观测流行病学研究涉及3,137名来自美国,墨西哥和巴西的男性 (2005-2009).
- 长度随访平均57个月,以追踪新的口腔HPV感染.
- 统计分析以确定HPV感染的发病率和相关风险因素.
主要成果:
- 口腔瘤性HPV的发病率为每1000个月的人中2.4个.
- 口服HPV发病率在不同年龄组和整个研究期间保持不变.
- 口服HPV感染的重要风险因素包括酒精消费,拥有男性性伴侣,增加终身女性伴侣,进行口交和高等教育.
结论:
- 男人面临着获得口腔HPV感染的持续终身风险.
- 识别风险因素有助于制定有针对性的预防战略.
- 赶上HPV疫苗接种计划可能有效地减少新感染和随后的OPC病例.
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