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Updated: Jun 10, 2025

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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Published on: January 20, 2019

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一个SIRT7依赖的乙化开关通过Pax5调节早期B细胞分化和血统承诺

Andres Gamez-Garcia1, Maria Espinosa-Alcantud1, Alberto Bueno-Costa2

  • 1Chromatin Biology Laboratory, Josep Carreras Leukemia Research Institute, Badalona, Spain.

Nature immunology
|October 18, 2024
PubMed
概括

酶SIRT7通过去除乙基来稳定Pax5,这是B细胞发育中的关键蛋白质. 这种相互作用对B型淋巴发育至关重要,可能表明B细胞急性淋巴细胞白血病的良好预后.

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