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关于YTHDF2 O-GlcNAc修饰在椎间盘退化病变发生的新视角

Liangjie Lu1, Lijun Wang2, Minjie Yang3

  • 1Department of Orthopedics, Ningbo Medical Center Li Huili Hospital, Li Huili Hospital, Affiliated to Ningbo University, No.57 Xingning Road, Yinzhou District, Ningbo, 315040, Zhejiang Province, China. 2380179@tongji.edu.cn.

Molecular medicine (Cambridge, Mass.)
|October 18, 2024
PubMed
概括

YTHDF2蛋白的O-GlcNAc修饰稳定了CCNE1mRNA,促进了细胞循环,并预防了椎间盘退化 (IDD). 这一发现为IDD提供了一个新的治疗点.

关键词:
在CCNE1中,细胞循环的细胞周期椎间盘退化 椎间盘退化O-GlcNAc 修饰的改变氧化应激是一种氧化应激.这就是YTHDF2的原因.

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