处方他类药物作为伊朗普通人口心血管疾病的首要预防的最佳风险值:一个益处-危害建模研究
Davood Khalili1,2,3, Hassan Saadati4, Hamid Reza Baradaran5,6
1Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
BMC cardiovascular disorders
|October 18, 2024
概括
作为初级心血管疾病 (CVD) 预防的他类药物治疗提供了好处,但也有风险. 开始服用他类药物的最佳值因年龄和性别而异,从18%到28%的10年心血管疾病风险.
科学领域:
- 心血管医学 心血管医学
- 预防性心脏病学 预防性心脏病学
- 卫生经济学 卫生经济学
背景情况:
- 类药物广泛用于心血管疾病 (CVD) 的初级预防.
- 它们的使用涉及有益影响和潜在不良事件之间的平衡.
- 确定最佳启动值对于最大化净收益至关重要.
研究的目的:
- 确定在一般人群中启动他类药物治疗的最佳10年心血管疾病 (CVD) 风险值.
- 考虑他类药物的益处和危害,并纳入患者的偏好.
- 将这些门按年龄和性别分层.
主要方法:
- 采用了量化利益与危害平衡模型.
- 数据包括他类药物的效果估计,来自伊朗调查的患者偏好,以及来自全球疾病负担研究的心血管疾病发病率.
- 分析的重点是40至75岁的个人,以前没有心血管疾病,计算了不同风险水平,年龄和性别的益处-危害指数.
主要成果:
- 与女性 (24-28%) 相比,男性 (18-23%) 观察到较低的10年心血管疾病风险值来启动他类药物.
- 年轻人 (40-45岁) 的临界值较老年人 (70-75岁) (23%的男性,28%的女性) 低 (18%的男性,24%的女性).
- 这些门包括从心痛到心血管疾病死亡率的结果.
结论:
- 在初级预防中使用他类药物处方的最佳10年心血管疾病风险值取决于年龄和性别,范围为18%至28%.
- 这项研究表明,男性和女性的特定硬性心血管疾病风险值在7.5%至10%之间.
- 这些发现有助于为预防心血管疾病做出个性化他类药物治疗决策.
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