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在子宫内膜制备的温和刺激方案中hCG触发是否对冷解胚胎移植的妊娠结果有任何影响?

Samaneh Kashi¹, Arezoo Arabipoor¹, Zahra Zolfaghari²

¹Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

Reproductive biology and endocrinology : RB&E

|October 18, 2024

概括

在轻度刺激的冷胚胎转移 (FET) 周期中,人类胆管激素 (hCG) 触发没有影响怀孕结果. 胚胎阶段,特别是囊胚转移,是这些周期中活产率的唯一显著预测因素.

科学领域:

生殖内分泌学生殖内分泌学
在体外受精 (IVF)

背景情况:

关于在冷胚胎移植 (FET) 周期中与轻度刺激 (mST) 协议触发人类胆管性淋巴激素 (hCG) 的研究有限.
这项研究调查了hCG触发对mST-FET循环中怀孕结果的影响,使用了Letrozole和Gonadotropins.

研究的目的:

评估hCG触发对mST-FET周期内植入率,临床怀孕率 (CPR) 和活产率 (LBR) 的影响.
在mST-FET周期中确定活产率的预测因素.

主要方法:

对409名接受mST-FET周期 (2020-2022) 的患者进行了回顾性队列研究.
患者被分为自发排卵 (n=138) 和hCG触发器 (n=271) 组.
怀孕结果进行了比较;多变量逻辑回归确定了LBR预测因素.

主要成果:

自发排卵和hCG触发组之间的植入率 (0.65对0.60),心肺复苏 (37%对39.7%) 或LBR (35.5%对37.3%) 没有显著差异.
多变量分析表明,只有移植胚胎的阶段 (胚胎囊与裂变) 能够显著预测LBR (OR: 2.33,95%CI: 1.41-3.86).

结论:

在mST-FET周期中,hCG触发不会显著改变怀孕结果.
囊胞胚胎移植是这种患者群体中活产率的主要预测因素.
建议进行进一步的前性研究,采用更大的样本大小来验证这些发现.

关键词:

在FET中,FET是FET.在冷胚胎移植过程中,冷胚胎被移植.在 LH 激增时, LH 激增.轻度刺激-FETET是一种轻度刺激.自发的排卵自发的排卵.这是一种hCG触发器.

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