最近的放射治疗可以减少患有食道癌的患者的心脏相关死亡:SEER数据库分析分析
Yuta Sato1, Rei Umezawa1, Takaya Yamamoto1
1Department of Radiation Oncology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-chou, Aoba-ku, Sendai, 980-8574, Japan.
Cardio-oncology (London, England)
|October 18, 2024
概括
放射治疗的近期进展显著减少了食道癌症患者的心脏相关死亡. 这项研究表明,与早期方法相比,使用现代放射治疗技术治疗的患者的治疗结果有所改善.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 辐射疗法 辐射疗法
背景情况:
- 用放射治疗治疗的食道癌症幸存者患有与心脏有关的死亡率很高.
- 近年来,放射治疗技术取得了显著的进步.
研究的目的:
- 研究用放射治疗治疗的食道癌症患者心脏病死亡率的趋势.
- 为了确定放射治疗的进步是否改善了长期的心脏结果.
主要方法:
- 利用SEER数据库分析了8297名接受放射治疗的患者的死亡原因 (2004-2015年).
- 结果与5149名仅接受手术治疗的患者进行了比较.
- 分析了基于瘤位置和治疗期间的心脏相关死亡率.
主要成果:
- 与宫/上胸瘤相比,中腹食道瘤 (较高的辐射剂量) 的放射治疗组中观察到较高的与心脏相关的死亡率 (p=0.017).
- 手术组显示,中/腹食道瘤的与心脏相关死亡率较低的趋势 (p=0.063).
- 与2004-2009年相比,在2010-2015年期间接受放射治疗的放射治疗组中发现心脏相关死亡率明显较低 (p=0.011).
结论:
- 放射治疗的最新进展导致了辐射引起的心脏病的减少.
- 现代放射治疗技术似乎可以减轻食道癌症患者的心脏风险.
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