早期发病的Luminal A乳腺癌的增长率与过度饮酒模式相关
Jianjiu Chen1, Rebecca Kehm1,2, Wan Yang1,2
1Department of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, Columbia University, New York, NY, 10032, USA.
Breast cancer research : BCR
|October 18, 2024
概括
增加的酒精消费,包括过度饮酒,与年轻女性早期乳腺癌 (BC) 的增加有关. 这项研究发现了酒精摄入模式和特定的BC亚型之间的相关性,这表明酒精在BC趋势中发挥了作用.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 乳腺癌 (BC) 发病率在美国年轻女性中正在上升.
- 酒精消费是激素受体阳性乳腺癌的已知危险因素,在这个人口群体中增长最快.
研究的目的:
- 调查酒精消费,特别是暴饮暴饮的趋势与40岁以下诊断的女性乳腺癌之间的相关性.
- 通过使用来自监测,流行病学和最终结果 (SEER) 癌症注册表的数据来分析趋势.
主要方法:
- 生态研究设计,检查酒精消费和BC发生率.
- 利用10年滞后模型和累积的10年累积暴露模型来考虑延迟.
- 分析了来自SEER癌症注册表的乳腺癌数据.
主要成果:
- 适度和重度的酒精消费与Luminal A乳腺癌有关.
- 在滞后和累积模型中,过度饮酒与早期发病的Luminal A和Luminal B乳腺癌的增加率有显著的关联.
- 没有发现过度饮酒与ERBB2丰富或三阴性早期乳腺癌之间有显著的关联.
结论:
- 研究结果支持这样一个假设:增加的酒精摄入量,包括过度饮酒,有助于早期乳腺癌的发病率上升.
- 强调酒精消费模式对年轻女性特定乳腺癌亚型的潜在影响.
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