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纳米技术辅助的CAR-T细胞疗法用于瘤治疗

Yixin Wang^1,2,3, Allie Barrett¹, Quanyin Hu^1,2,3

¹Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

|October 19, 2024

概括

化学抗原受体 (CAR) -T细胞疗法在固体瘤中显示出前景. 纳米技术增强了CAR-T细胞,以克服诸如不良透和毒性等挑战,改善抗瘤活性.

科学领域:

免疫治疗是一种免疫疗法.
纳米技术纳米技术
在瘤学瘤学.

背景情况:

卡特-T细胞疗法对血液癌症有效,但在固体瘤中面临挑战,包括有限的透,功能下降和毒性.
关键的局限性包括瘤微环境内的T细胞透和扩张不足,移植后的快速功能衰退以及严重的目标外毒性.

研究的目的:

审查阻碍固体瘤中CAR-T细胞治疗的障碍.
突出基于纳米技术的策略,以提高CAR-T细胞的有效性和安全性.
探索纳米粒子辅助CAR-T细胞疗法的未来潜力.

主要方法:

关于CAR-T细胞治疗和纳米技术应用的当前文献的综述.
分析使用多功能纳米粒子修改CAR-T细胞的策略.
讨论纳米粒子介导编程用于CAR-T细胞优化.

主要成果:

纳米粒子可以使CAR-T细胞克服免疫抑制瘤微环境.
多功能纳米粒子增强CAR-T细胞功能,减少对正常组织的毒性.
纳米粒子介导编程为改进制造和成本效益提供了潜力.

结论:

纳米技术提出了创新的解决方案,以加强对固体瘤的CAR-T细胞疗法.
纳米粒子辅助的CAR-T细胞策略有望改善抗瘤活性,降低毒性和更广泛的临床可访问性.
进一步研究纳米粒子介导的CAR-T细胞编程对于推进癌症治疗至关重要.

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