儿童大脑和外围组织氧度的参考值:一项临床TD-NIRS研究
Valeria Calcaterra1,2, Michele Lacerenza3, Virginia Rossi2
1Pediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, Pavia, Italy.
Acta paediatrica (Oslo, Norway : 1992)
|October 19, 2024
概括
这项研究使用时域近红外光谱 (TD-NIRS) 建立了小儿组织氧化的参考范围. TD-NIRS为大脑和手臂组织提供精确的测量,这对未来儿童临床应用至关重要.
科学领域:
- 生物医学光学 生物医学光学
- 身体生理学 身体生理学
- 儿科医学 儿科医学
背景情况:
- 使用近红外光谱法 (NIRS) 的非侵入性组织氧测具有可重现性问题,限制了临床使用.
- 时间域-NIRS (TD-NIRS) 提供了更高的精度,但缺乏用于建立临床值的儿科数据.
- 建立儿科参考范围对于准确的临床评估至关重要.
研究的目的:
- 建立使用TD-NIRS的儿童大脑和中上臂 (MUA) 组织血液动力学的参考范围.
- 在儿科队列中探索TD-NIRS衍生的血液动力学参数和auxological变量之间的相关性.
- 评估TD-NIRS在儿科患者中的精度和可重复性.
主要方法:
- 在350名儿童中,对大脑皮层和MUA进行了TD-NIRS测量.
- 使用NIRSBOX组织氧计进行数据采集.
- 收集了形态和临床数据,以与TD-NIRS参数相关联.
主要成果:
- TD-NIRS在大脑和MUA区域中展示了StO2和tHb的高精度和低标准偏差.
- 在TD-NIRS测量中没有观察到用户依赖.
- 血液动力学值的趋势在大脑和外围区域之间因年龄和耳道学参数而有所不同.
结论:
- 这项研究为健康的儿童群体提供了基本的静止状态光学和血液动力学参考值.
- 这些发现为确定儿科组织血液动力学中临床相关偏差奠定了基础.
- 与人体测量和人口统计数据的相关性为儿童组织血液动力学发展提供了洞察力.
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