黄素作为瘤治疗中的补充疗法:系统性审查
Lisa C Gutsche1, Jennifer Dörfler2, Jutta Hübner2
1Klinik für Innere Medizin II, Hämatologie und Internistische Onkologie, Universitätsklinikum Jena, Am Klinikum 1, Jena, 07747, Germany. lisacgutsche@gmail.com.
在癌症患者中,黄素有望减少口腔粘膜炎和减肥. 然而,由于研究结果和局限性各异,其整体有效性需要进一步进行高质量的研究.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 综合医学是一个整体的医学.
背景情况:
- 从黄中提取的黄素被癌症患者用作补充疗法.
- 目前正在系统评估黄素在癌症治疗中的益处和风险的证据.
研究的目的:
- 系统地审查癌症患者对黄素补充剂的临床证据.
- 总结黄素治疗的潜在益处和风险.
主要方法:
- 在2024年1月对五个数据库 (Embase,Cochrane,PsycInfo,CINAHL,Medline) 进行系统搜索.
- 包括34个随机对照试验 (2580名患者) 关于黄素的使用,有效性和危害.
- 偏差风险评估使用Cochrane修订的偏差风险工具 2.0.0.
主要成果:
- 研究涉及患有头癌,乳腺癌,前列腺癌和结直肠癌的患者.
- 黄素的施用是局部或全身的,报告的结果异构.
- 观察到口腔粘膜炎和体重减轻的显著减少;然而,研究中存在中度至高偏差风险.
结论:
- 黄素显示出治疗癌症患者的粘膜炎和减肥的潜力.
- 异质的结果和方法上的局限性阻止了关于黄素有效性的最终结论.
- 需要进行更高质量的研究,以确定在癌症治疗中使用黄素的明确建议.
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