肝病流行病学:全球疾病负担和预测的研究趋势
Jia Xiao1,2, Fei Wang3,4, Yuan Yuan5
1Department of Gastroenterology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences, Qingdao, 266071, China. edwinsiu@connect.hku.hk.
Science China. Life sciences
|October 19, 2024
概括
全球肝病负担正在上升,特别是与酒精有关的肝病 (ALD) 和与代谢功能障碍相关的脂肪性肝病 (MASLD). 研究资金和重点正在转变,但肝脏疾病,特别是ALD的药物开发仍然有限.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 全球健康 全球健康
- 疾病流行病学 疾病流行病学
背景情况:
- 肝脏疾病是一个重大的全球健康挑战,流行病学趋势各不相同.
- 了解疾病负担和研究环境对于有效的公共卫生战略至关重要.
研究的目的:
- 评估全球肝病负担 (发病率,死亡率,DALYs) 并分析2000-2019年肝病学研究和药物开发趋势.
- 确定关键的研究领域,资金转移,以及主要肝脏疾病的治疗开发管道.
主要方法:
- 利用了2019年全球疾病负担研究的数据用于疾病指标.
- 分析了肝病学方面的出版趋势,资金数据和临床试验信息.
主要成果:
- 与酒精有关的肝病 (ALD) 和与代谢功能障碍相关的脂肪性肝病 (MASLD) 的患病率增加;对于HBV,HCV和肝癌的患病率下降.
- 高社会人口指数 (SDI) 的国家显示较低的死亡率和DALYs.
- MASLD和肝胆癌获得了更多的研究资金;肝肝器官通信是越来越多的研究重点,而ALD研究被低估了.
- 型肝炎病毒 (HCV),肝癌和MASLD主导了治疗发展,但全球仅批准了少数治疗肝病的新药,而ALD则没有.
结论:
- 肝脏疾病的负担正在演变,ALD和MASLD的显着增加.
- 肝病学研究越来越专注于MASLD和器官间通信,但像ALD这样的关键领域需要更多的关注.
- 尽管有研究努力,但新的肝病治疗药物,特别是ALD的管道仍然不足.
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