在患有库辛病的患者内镜下垂体手术后的鼻结局
Nadeem R Kolia1,2, Cara M Fleseriu1,3, Subhanudh Thavaraputta3
1Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
The Annals of otology, rhinology, and laryngology
|October 19, 2024
概括
患有库辛病 (CD) 的患者在内镜内接近 (EEA) 手术后经历了长期的鼻腔质量损害. 与对照组不同,他们的症状不会在六个月内消失,这凸显了CD患者手术后的特殊挑战.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经外科 神经外科
- 内分泌学 在内分泌学.
背景情况:
- 内镜内鼻治疗方法 (EEA) 是对 pituitary 瘤的标准,通常会导致最小的鼻腔发病率.
- 库辛病 (CD) 患者在EEA后可能会有独特的,长期的鼻质量 (QOL) 问题.
研究的目的:
- 为了在库辛病患者中比较术后鼻性QOL与接受EEA的对照.
- 识别受影响的特定QOL域及其恢复轨迹.
主要方法:
- 对接受EEA的CD患者和匹配的对照进行了回顾性研究.
- 通过Sino-Nasal Outcome Test (SNOT-22) 在手术后1,3个月和6个月的得分来衡量初级结果.
主要成果:
- 两组之间1个月或3个月后SNOT-22分数没有显著差异.
- 与对照组相比,CD患者在6个月内SNOT-22得分明显降低 (27.4比2.8,P=.039).
- 对照SNOT-22得分在6个月后正常化;CD得分没有改善 (P=.726). 睡眠和面部领域在CD患者中受到影响最大.
结论:
- 库辛病患者在经过EEA后表现出长期的术后鼻腔QOL损伤.
- 与对照组不同的是,CD患者的QOL在六个月内不会正常化.
- 面部和睡眠领域显示持续的发病率,表明CD患者在EEA后面临的具体挑战.
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