腹部海马内部神经元控制着情境关联的灭绝和复发
Anthony F Lacagnina1, Tri N Dong1, Rasika R Iyer1
1Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Cell reports
|October 19, 2024
概括
语境记忆的灭绝涉及腹部海马体中的体静止素内部神经元 (SST-INs). 操纵SST-IN双向改变了结行为,这表明它在记忆灭绝中发挥了关键作用.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 记忆研究 记忆研究
背景情况:
- 语境记忆对于生存至关重要,但在过时时需要灭绝.
- 记忆灭绝背后的神经回路仍然不太清楚.
- 现有的理论认为,灭绝形成了与原始关联竞争的新记忆.
研究的目的:
- 调查上下文记忆灭绝的电路机制.
- 为了确定参与灭绝过程的特定神经元群体.
- 探索腹部海马内部神经元在记忆灭绝中的作用.
主要方法:
- 在动物中恐惧调节和灭绝范式.
- 对特定内部神经元群体的光遗传学操纵 (体静止素和帕瓦尔胺).
- 实时监测与行为相关的神经元活动.
主要成果:
- 对上下文恐惧条件的灭绝激活了腹部海马体中的体静止素内部神经元 (SST-INs).
- SST-IN活动与从结中脱离的行为过渡相关.
- 双向调制的SST-INs光遗传学激活或抑制的上下文特定的结行为.
- 在食欲 (糖) 调节中观察到类似的效应,SST-IN抑制引发了复发.
结论:
- 室内海马SST-IN在记忆灭绝中起着至关重要的作用,不论其情感价值如何.
- 通过破坏既定的行为模式,SST-IN可以调节情绪反应.
- 这些发现为适应性行为变化的神经基础提供了新的见解.
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