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细胞质精子注射 (ICSI) - 一个系统的文献审查
Vyacheslav Notanovich Lokshin1,2, Aigerim Temirkhanovna Abshekenova1,2, Gian Carlo Di Renzo3,4
1NAO KazNMU named after S.D. Asfendiyarov, Almaty, Kazakhstan.
概括
孕激素培养卵巢刺激 (PPOS) 在IVF/ICSI中提供了好处,产生了更多的胚胎和更少的OHSS病例. 这种方法对反应不佳的患者,PCOS患者和接受生育治疗的老年妇女尤其有利.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 辅助生殖技术 辅助生殖技术
背景情况:
- 孕激素主导的卵巢刺激 (PPOS) 使用孕激素来防止卵巢刺激期间过早的黄激素 (LH) 激增.
- 这与使用性腺激素释放激素 (GnRH) 类似物或对抗剂的传统方法形成鲜明对比.
研究的目的:
- 评估孕激素治疗对卵巢刺激和LH激增控制的影响.
- 与标准方案相比,评估PPOS在卵细胞采集,胚胎质量和儿童的长期结果方面的有效性和适用性.
主要方法:
- 2015年1月至2021年4月期间发表的随机对照试验的文献综述.
- 关键词包括"孕激素原卵巢刺激"",PPOS"",微型化孕激素"",美德克西孕激素"和"双激素".
- 分析重点是对IVF/ICSI进行受控卵巢刺激 (COS) 的队列,干预和协议方案.
主要成果:
- 在IVF/ICSI中,PPOS导致胚胎数量增加,卵巢过度刺激综合征 (OHSS) 的发生率降低.
- 刺激持续时间,卵细胞检索数和MII卵细胞计数与标准方案相比.
- 儿童的长期安全性在PPOS和对照组之间没有显著差异.
结论:
- 在IVF/ICSI中,PPOS是控制卵巢刺激的有效策略.
- 特定的患者群体,包括卵巢反应较差,PCOS患者,晚年母亲和卵细胞捐赠者,显示PPOS的最显著的好处.
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