芬兰1型糖尿病患者的全因死亡率和与之相关的因素
Elena Putula1, Tuuli Kauppala2, Sini Vanhamäki2
1Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland; Tampere University Hospital, Department of Internal Medicine, Tampere, Finland.
Journal of diabetes and its complications
|October 19, 2024
概括
1型糖尿病 (DM1) 在芬兰显著增加死亡风险. 关键因素包括慢性病 (CKD) 风险,心血管疾病和心理健康,突出了针对性干预的领域.
科学领域:
- 内分泌学和新陈代谢学
- 腎臟病學 (nephrology) 是一種醫學.
- 公共卫生 公共卫生
背景情况:
- 1型糖尿病 (DM1) 与全因死亡率的增加有关.
- 伴随性疾病和风险因素管理对于DM1患者的治疗结果至关重要.
- 了解DM1的死亡预测因素对于公共卫生战略至关重要.
研究的目的:
- 评估并发症和风险分类对DM1患者全因死亡率的影响.
- 评估慢性病 (CKD) 风险,HbA1c和LDL胆固醇对死亡率的影响.
- 确定导致DM1患者过度死亡的关键风险因素.
主要方法:
- 来自芬兰糖尿病登记处 (2018-2022) 的45801名DM1患者的分析.
- 使用标准化死亡率 (SMRs) 将DM1患者死亡率与非糖尿病芬兰人口进行比较.
- 普森回归建模用于确定风险因素对SMR的影响.
主要成果:
- DM1患者的总体SMR为1.84,年龄在30-49岁之间达到峰值.
- 在末期病 (2.66),心血管疾病 (1.92) 和高/非常高的CKD风险 (3.64) 中观察到显著的死亡率比率.
- 升高的HbA1c (≥8%) 和LDL胆固醇 (≥2.6 mmol/l) 与增加的死亡率 (分别为1.27和1.33) 相关.
结论:
- 在芬兰,DM1患者的死亡率过高.
- 干预措施应优先考虑脏和心血管风险因素.
- 建议增加对心理健康的关注,以减轻与DM1相关的死亡率.
相关概念视频
Diabetes: Symptoms, Diagnosis, and Complications
511
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
511
Diabetes Mellitus: Overview and Type I Subtype
2.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.5K
Diabetes Mellitus: Type 2 and Gestational
2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
Pathophysiology of Diabetes
874
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
874
Psychoneuroimmunology: Diabetes and Cancer
24
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
24
Diabetes: Management and Pharmacotherapy
237
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
237


