四肢肌肉层厚度及其与重症患者的虚弱相关:一项前性观察性研究
Vijay Sundarsingh1, R Manoj Kumar2, Manjunath Kulkarni3
1Department of Critical Care Medicine, Father Muller Medical College, Mangalore, India.
Journal of critical care
|October 19, 2024
概括
这项研究发现,通过超声波测量下四肢肌肉层厚度 (QMLT),独立地与严重病情的老年患者的脆弱性有关. 虚弱患者的降低QMLT与28天死亡率的增加相关,这表明其在虚弱评估中的有用性.
科学领域:
- 老年学是一门学科.
- 关键护理医学 关键护理医学
- 诊断成像 诊断成像 诊断成像
背景情况:
- 脆弱性显著影响了重症患者的结果.
- 肌肉超声波,特别是四肢肌肉层厚度 (QMLT),是肌肉质量和肌肉脆弱的潜在标志物.
- 之前的研究还没有研究QMLT与这个人群的脆弱性之间的关联.
研究的目的:
- 确定四肢肌肉层厚度 (QMLT) 与重症老年患者的脆弱性之间的关联.
- 探索QMLT,脆弱性严重程度和死亡率之间的关系.
主要方法:
- 印度ICU的前性,观察性,单中心研究.
- 招募的患者年龄大于65岁,通过临床虚弱度量表 (CFS) 评估基线虚弱.
- 在入院时通过超声波测量QMLT;使用多变量回归方法比较非脆弱 (CFS 1-4) 和脆弱 (CFS ≥5) 组之间的特征.
主要成果:
- 包括120名患者;65%是虚弱的,死亡率更高 (37.17%对16.66%).
- 虚弱的患者表现出明显较低的QMLT (1.77厘米 vs 2.21厘米,p < 0.001),随着CFS的增加而下降.
- 在脆弱患者中,较低的QMLT独立地与28天死亡率增加有关 (48.97%对18.18%,p = 0.003).
结论:
- 四肢肌肉层厚度 (QMLT) 独立地与重病老年患者的脆弱性有关.
- 随着临床脆弱性量表 (CFS) 评分的增加,QMLT逐渐下降.
- 将QMLT测量与CFS相结合,可以增强脆弱性评估,并改善严重病情的老年患者的临床决策.
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