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通过调节METTL3介导的Ctsk m6A修饰,T-2毒素诱导了冠状细胞细胞外基质降解

Bing Zhang1, Haonan Li2, Fang Qi2

  • 1Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, Heilongjiang, China; National Healthy Commission and Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology, Harbin Medical University (23618504), Heilongjiang Provincial Laboratory of Trace Element and Human Health, Harbin Medical University, Harbin 150081, China; School of Public Health, Beihua University, Jilin 132013, Jilin, China.

International immunopharmacology
|October 19, 2024
PubMed
概括

在卡辛-贝克病 (KBD) 中,T-2毒素会导致软骨损伤. 研究人员发现,METTL3介导的m6A修饰的Cathepsin K (Ctsk) 驱动这种损伤,提供了一个潜在的治疗点.

关键词:
软骨损伤是指软骨的损伤.卡塞普辛K (Ctsk) 的意思甲基转移酶3 (METTL3) 是一种这是一种T-2毒素.

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