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Updated: Jul 20, 2026

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单细胞剖析揭示了在人切割感染期间缺氧诱导因子信号传递的保留作用

Zachary Van Roy1, Gunjan Kak1, Lee E Korshoj1

  • 1Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Cell reports. Medicine
|October 19, 2024
PubMed
概括

切除术感染涉及特定的免疫细胞和代谢变化. 准缺氧诱导因子 (HIF) 信号可能为这些复杂的神经外科感染提供新的治疗方法.

关键词:
在T细胞,T细胞.进行了骨切除术 (craniotomy).颗粒细胞是颗粒细胞.人类 人类 人类 人类 人类 人类 人类缺氧诱导因子的诱导因子免疫学 免疫学 免疫学免疫代谢的免疫代谢.感染的感染感染.来自骨髓细胞的抑制细胞.神经外科神经外科手术

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
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Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
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