研究优化发酵过程,以增强由益生菌促进尿酸降解的研究
Hanwei Zheng1, Zhiqing Liu1, Hao Zheng1
1Lab of Applied Biocatalysis, School of Food Science and Engineering, South China University of Technology, No. 381 Wushan Road, Guangzhou, Guangdong 510640, China.
Journal of biotechnology
|October 19, 2024
概括
优化Lactiplantibacillus plantarum FS4722培养条件显著提高了其减少尿酸的活性. 这种增强为新型抗痛风食品和补充剂铺平了道路.
科学领域:
- 微生物学 微生物学
- 生物技术是生物技术.
- 食品科学 食品科学 食品科学
背景情况:
- 高尿酸水平与痛风和其他健康问题有关.
- 乳植物植物菌植物 FS4722 显示出尿酸减少的潜力.
- 优化发酵是最大化微生物活动的关键.
研究的目的:
- 为优化L. plantarum FS4722.的培养基成分和发酵条件.
- 为了增强L. plantarum FS4722.的尿酸降低活性.
- 探索功能性食品和药品中的应用.
主要方法:
- 响应表面的方法用于优化.
- 优化的关键参数包括葡萄糖,酵母提取物粉末,核酸添加,发酵时间,初始pH,温度和注射剂大小.
- 尿酸降解潜力是根据核酸降解能力进行评估的.
主要成果:
- 最佳介质: 25.61 g/L 葡萄糖, 26.86 g/L 酵母提取物粉, 0.48 g/L 核酸.
- 最佳条件:发酵时间10小时,pH值6.5,温度33°C,0.0%的注射剂.
- 在优化条件下,核酸降解增加了41.9倍.
结论:
- 优化条件显著提高L. plantarum FS4722的尿酸降低能力.
- 这些发现支持开发功能性食品和补充剂,以控制尿酸水平.
- 这项研究突出了L. plantarum FS4722在药物应用中治疗痛风的潜力.
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