在患有双相情感障碍和没有双相情感障碍的年轻人中,双相情感障碍的多基因风险的神经认知相关性
Xinyue Jiang1, Clement Zai2, Megan Mio3
1Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada.
Journal of affective disorders
|October 19, 2024
概括
双相情感障碍 (BD) 的高多基因风险与青少年的神经认知功能较差有关,包括患有BD和健康对照的人. 这种遗传风险会影响青少年的情感处理,决策和注意力.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
背景情况:
- 双极性障碍 (BD) 与成人和青少年的神经认知能力受损有关.
- 患有BD的年轻人神经认知缺陷的遗传基础尚未得到充分理解.
- 本研究研究了BD (BD-PRS) 的多基因风险评分与青少年的神经认知之间的关系.
研究的目的:
- 检查BD-PRS与青少年神经认知表现之间的关联.
- 为了比较BD和健康对照 (HC) 个体中的这些关联.
主要方法:
- 包括129名年轻人 (72名BD,57名HC),年龄在13-20岁之间,欧洲血统.
- 评估神经认知使用六个剑桥神经心理测试自动化电池任务.
- 使用一般线性模型分析BD-PRS和神经认知复合分数之间的关联,控制共变量.
主要成果:
- 在总体样本中,较高的BD-PRS与较差的情感处理,决策和持续的注意力相关.
- 在BD组中,较高的BD-PRS与持续注意力较差有关.
- 在HC组中,较高的BD-PRS与较差的情感处理有关.
结论:
- 来自成年基因组范围的关联研究的BD多基因风险与年轻人的神经认知缺陷有关.
- 研究结果表明,在患有BD和没有BD的年轻人中,共同的遗传因素对神经认知有影响.
- 要了解这些关联的发展轨迹,需要进行纵向研究.
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