通过多种染色学和离子化方法研究化学空间覆盖面,使用通过被动采样收集的表面和饮用水的非定向分析
Angela L Batt1, Laura D Brunelle2, Natalia S Quinete3
1U.S. Environmental Protection Agency, Office of Research and Development, Center for Environmental Solutions and Emergency Response, Cincinnati, OH 45268, United States.
这项研究评估了用于检测水中的化学污染物的非向分析方法. 对比了不同的染色学和电离技术,以描述环境水样中覆盖的化学空间.
科学领域:
- 环境化学环境化学
- 分析化学 分析化学
- 质谱测量质量谱测量
背景情况:
- 水中的化学污染物对生态系统和人类健康构成风险.
- 非定向分析对于在复杂的环境矩阵中识别未知的污染物至关重要.
研究的目的:
- 综合评估和比较不同的液态染色学 (LC) 分离和高分辨率质谱学 (HRMS) 检测方法,用于水中广泛的化学污染物选.
- 评估各种色谱 (C18,HILIC) 和电离 (ESI,APCI) 技术提供的化学空间覆盖面.
主要方法:
- 利用液态色谱与四极飞行时间 (Q-ToF) 和轨道飞行器高分辨率质谱相结合.
- 评估的逆相C18和水友相互作用液态染色学 (HILIC) 列.
- 测试了正负两种模式下的电喷射电离 (ESI) 和大气压化学电离 (APCI).
- 雇佣了一个可疑的选图书馆超过1300种环境污染物.
主要成果:
- 在使用极地有机化学集成样本 (POCIS) 收集的地表和饮用水样本中检测到数百种化学特征.
- 与C18相比,HILIC保留了更多的极性污染物.
- 通过嫌疑人选和数据库搜索,暂时确定了100多种化学品.
结论:
- 该研究系统地描述了由不同的LC-HRMS工作流覆盖的化学空间,用于环境水分析.
- 方法选择对检测到的化学污染物的范围和类型产生重大影响.
- 为优化水质监测的非定向分析策略提供了基础.
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