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Updated: Jun 10, 2025

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
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Published on: August 9, 2022

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同时的XRD-DSC识别了正确的药物-聚合物溶解性和混合性,用于反转变型固体形式

Mustafa Bookwala1, Jiawanjun Shi2, Ira S Buckner1

  • 1School of Pharmacy and Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Ave, Pittsburgh, PA 15282, USA.

Journal of pharmaceutical sciences
|October 19, 2024
PubMed
概括

同时的X射线衍射 (XRD) 和差异扫描热度计 (DSC) 准确地确定了胺固体形式的热力学特性. 这种结合技术避免了经常仅用DSC看到的误解,这对于无形固体分散稳定性至关重要.

关键词:
无形固体分散的分散.溶解终点是溶解的终点.异能热的固体形成了固体形式.物理稳定性 物理稳定性多态依赖性溶解度的多态依赖性多态转换的多态转换.同时进行XRD-DSCC.

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