在患有或没有SARS-CoV-2血清阳性儿科结核病的炎症性细胞因子反应
Nathella Pavan Kumar1, Sarath Balaji2, Poorna Ganga Devi1
1ICMR - National Institute for Research in Tuberculosis, Chennai, India.
The Journal of infection
|October 19, 2024
概括
结核病 (TB) 和SARS-CoV-2血清阳性儿童在诊断时表现出明显的炎症性细胞因子概况,IFN-γ,IL-2,TNFα,IL-1α和IL-6水平升高. 这些差异在治疗期间减少.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 儿科 儿科 儿科
背景情况:
- 结核病 (TB) 仍然是一个重大的全球卫生挑战,特别是在流行地区.
- 在儿童中结核病和SARS-CoV-2感染的同时发生提出了复杂的免疫学问题.
- 了解这些感染之间的相互作用对于有效的管理和治疗至关重要.
研究的目的:
- 鉴定和比较被诊断患有结核病的儿童的炎症性细胞因子概况.
- 调查SARS-CoV-2血清阳性对这些炎症反应的影响.
- 探索结核病治疗期间细胞因子水平的纵向变化,与SARS-CoV-2状态相关.
主要方法:
- 一项涉及60名患有结核病的儿童的队列研究,分为两组:SARS-CoV-2血清阳性 (CoV2+) 和血清阴性 (CoV2-).
- 细胞因子水平 (包括IFN-γ,IL-2,TNFα,IL-1α,IL-6,IL-1β和IL-18) 在诊断后的基线,3个月和6个月被测量.
- 在细胞因子水平和SARS-CoV-2 IgG尖端蛋白水平之间进行了相关性分析.
主要成果:
- 在基线时,与Cov2+儿童相比,Cov2+儿童的炎症性细胞因子 (IFN-γ,IL-2,TNFα,IL-1α,IL-6) 水平显著更高,IL-1β和IL-18水平较低.
- 在3个月和6个月后的组之间没有观察到细胞因子概况的显著差异.
- 在两组6个月的治疗期间,细胞因子水平普遍下降,大多数细胞因子和SARS-CoV-2 IgG水平在基线和3个月的Cov2+组之间存在正相关性.
结论:
- 这项研究为患有结核病和SARS-CoV-2血清阳性同时存在的儿童的独特炎症反应提供了新的见解.
- 这些发现凸显了结核病治疗背景下,SARS-CoV-2相关炎症变化的短暂性质.
- 这项研究有助于了解儿童双重感染的免疫病原发生,并可能指导未来的治疗策略.
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