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目前的趋势和可用的证据,低水平的激光治疗骨质放射性缩:一个范围审查

Larissa Di Carvalho Melo¹, Bruna Bastos Silveira¹, Mylene Martins Monteiro¹

¹University of Brasilia, Laboratory of Oral Histopathology, School of Health Sciences Faculty, Brasília Brazil.

Photodiagnosis and photodynamic therapy

|October 19, 2024

概括

低水平激光疗法 (LLLT) 在治疗和预防骨质放射性瘤方面表现有前途. 然而,当前研究中的不一致的激光参数阻碍了标准化方案,需要进一步研究临床整合.

科学领域:

生物医学工程生物医学工程
口腔和牙面部外科手术
在瘤学瘤学.

背景情况:

骨质放射性死 (ORN) 是放射治疗后的一种严重并发症.
低水平激光疗法 (LLLT) 正在探索其在管理ORN的治疗和预防潜力.

研究的目的:

对ORN治疗和预防中LLLT的当前趋势和证据进行范围审查.
确定现有研究中使用的共同LLLT协议和参数.

主要方法:

在主要数据库 (MEDLINE/PubMed,EMBASE,Web of Science) 和灰色文献中进行了全面的文献搜索.
在2024年1月15日进行的搜索中,没有语言或时间限制.
十九项研究符合审查的纳入标准.

主要成果:

在ORN管理中,LLLT用于治疗 (58%),预防 (21%),和联合 (21%) 的用途.
在41%的研究中使用了抗微生物光动力疗法 (aPDT),通常使用甲蓝.
在近红外 (780-904 nm) 和红 (660 nm) 波长的二极管激光器是常用的,主要是在连续发射模式.

结论:

在ORN中,LLLT展示了治疗和预防应用的潜力.
在研究中报告的激光参数的显著变化使标准化协议的建立变得复杂.
专注于协议标准化的进一步精心设计的临床试验对于ORN的LLLT可靠的临床整合至关重要.

关键词:

激光疗法是一种激光疗法.低水平的激光疗法.低水平的照明疗法低水平的照明疗法.骨质放射性缩 (Osteoradionecrosis) 是一种疾病,导致骨质放射性缩.照相生物调制疗法是一种照相生物调制疗法.光动力学疗法是一种光动力学疗法.审查审查审查审查

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