支气管检查研究中的利益冲突:自我报告是否足够?
Kaele M Leonard1, Timothy A Khalil1, Jacob Welch2
1Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN; Interventional Pulmonology Research, Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN; Multidisciplinary Assessment and Stratification of Lung Cancer with Biomarkers Laboratory (MASLAB), Vanderbilt University Medical Center, Nashville, TN.
Chest
|October 19, 2024
概括
在机器人辅助支气管检查研究中的利益冲突往往未被披露. 很大一部分向医生支付的费用没有被报告,这表明这项受欢迎的医疗技术的研究可能存在偏见.
科学领域:
- 肺部医学 肺部医学
- 医学伦理 医学伦理
- 卫生政策 卫生政策
背景情况:
- 机器人辅助支气管镜的采用量急剧增加,改变了肺结节治疗.
- 工业投资引发了对影响研究有效性的潜在利益冲突 (COI) 的担忧.
- 透明的COI自我报告对于研究完整性至关重要.
研究的目的:
- 评估机器人辅助支气管镜出版物中自我报告的COI的准确性.
- 将自我报告的数据与来自开放支付数据库的公开支付记录进行比较.
主要方法:
- 选了PubMed的机器人辅助支气管检查文章 (2016-2022年).
- 从前五大期刊中选择文章;从开放支付数据库中提取医生支付数据.
- 将作者披露的信息与来自支气管镜相关公司在文章提交前3年内记录的付款进行了比较.
主要成果:
- 分析了涉及75名美国医生的27篇文章.
- 在1700万美元的相关支付中,发现了990万美元 (57%),未披露.
- 91%的作者 (68/75) 有不完整的披露;80% (60/75) 甚至不包括食品/饮料支付.
结论:
- 在机器人辅助支气管镜研究中不一致地披露COI表明自我报告是不充分的.
- 建议采用更强大的,潜在的自动化,集中式披露系统.
- 解决披露差距对于保持对医学研究的信任至关重要.
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