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针对前列腺癌诊断的PSMA PET biopsy:来自多中心队列的初步经验
Enrico Checcucci1, Matteo Bauckneht2, Edoardo Cisero3
1Department of Surgery, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Turin, Italy.
Urology
|October 19, 2024
概括
前列腺特异性膜抗原正子发射断层扫描/计算机断层扫描 (PSMA-PET/CT) 引导的活检显示出比标准活检更高的癌症检测率,特别是在未经活检的患者中. 这种技术是诊断前列腺癌 (PCa) 的有希望的工具,特别是在高风险病例中.
科学领域:
- 泌尿外科瘤学 泌尿外科瘤学
- 医学成像医学成像
- 前列腺癌诊断的诊断方法
背景情况:
- 前列腺癌 (PCa) 诊断依赖于准确的组织采样.
- 标准活检 (SB) 方法在检测临床显著PCa (csPCA) 方面存在局限性.
- PSMA-PET/CT为PCa定位提供了新的成像见解.
研究的目的:
- 评估欧洲最初使用PSMA-PET/CT导向前列腺活检的经验.
- 为了比较PSMA-PET/CT导向活检与标准和MRI导向活检的检测率.
- 使用PSMA-PET/CT.识别与csPCA检测相关的因素.
主要方法:
- 在6个欧洲中心进行多中心观察队列研究.
- 以PSMA-PET/CT为指导的活检是通过认知或融合进行的.
- 对PCa和csPCA的检测率 (DR) 与标准活检 (SB) 和MRI指导活检的比较.
主要成果:
- 与SB相比,PSMA-PET/CT导向活检显示PCa和csPCA的DR显著更高 (P < .05).
- 检测率并没有显著超过MRI引导的活检.
- 与那些经过重复活检的患者相比,在未经活检的患者中表现优越.
- 4.8的SUVmax截止值是csPCA检测的最佳值.
结论:
- 在现实环境中,PSMA-PET/CT导向活检是PCa诊断的宝贵工具.
- 考虑PSMA-PET/CT向活检,用于怀疑高风险PCa的未经活检患者.
- 在重复活检场景中,PSMA-PET/CT导向活检可能比SB更好.
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