在患有甲状腺功能低下症的儿童中,腹腔大动脉内心介质厚度
Rehab Fawzy Abdel Mohsen Soliman1, Mohamed Hamdna Allah El Ghobashy2, Mona Hassan Hafez3
1General Organization for Teaching Hospitals and Institutes, Cairo, Egypt.
Pediatrics and neonatology
|October 19, 2024
概括
治疗甲状腺功能低下症可显著改善脂质样本,并减少腹腔大动脉内心介质厚度 (IMT). 这表明,管理甲状腺功能可以帮助预防动脉样硬化进展.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 诊断成像 诊断成像 诊断成像
背景情况:
- 甲状腺功能低下症与动脉样硬化有关,主要是由于不良的脂质样本.
- 内部介质厚度 (IMT) 是动脉样硬化的早期指标.
- 了解甲状腺功能低下症治疗对动脉样硬化标志物的影响至关重要.
研究的目的:
- 为了研究新诊断的甲状腺功能低下症患者的脂质谱和腹腔大动脉IMT的变化.
- 为了评估治疗的影响,并在一年内实现这些标志物的甲状腺功能减轻症.
主要方法:
- 对50名新诊断为甲状腺功能低下症 (先天性和获得性) 的患者进行前性队列研究.
- 测量包括病史,耳声学,血压,非禁食脂质概况,以及通过超声波的腹腔大动脉IMT.
- 患者在诊断时和治疗后一年被评估.
主要成果:
- 高基线胆固醇,甘油三和LDL水平在治疗后显著下降.
- 低基线HDL水平在治疗后显著增加.
- 腹腔大动脉IMT在治疗后显著下降,并实现了优甲状腺症.
结论:
- 甲状腺功能低下症的治疗和实现甲状腺功能良好症导致脂质特征显著改善 (降低胆固醇,甘油三,LDL;高高胆固醇).
- 腹腔大动脉IMT在治疗后显著下降,这表明动脉样硬化减少.
- 腹腔大动脉IMT测量是早期检测甲状腺功能低下患者的动脉样硬化的一种实用方法.
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