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Updated: Jun 10, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

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一个毫秒粗粒度模拟方法来破译在甘氨酸受体α1的全性大麻素结合

Alessio Bartocci1,2,3, Andrea Grazzi1,4, Nour Awad5

  • 1Institut de Chimie de Strasbourg, UMR7177, CNRS, Université de Strasbourg, Strasbourg Cedex, 67083, France.

Nature communications
|October 19, 2024
PubMed
概括

像THC和AEA这样的大麻素与甘氨酸受体 (GlyR) 上的多个部位结合,影响它们的功能. 这项研究揭示了这些结合位置,并确定了GlyR强化的主要残留物.

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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators07:41

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