休息状态网络变化是由实验性无声超声波暴露和与自我报告的噪音敏感性和烦相关的变化引起的
Caroline Garcia Forlim1,2, Leonie Ascone3, Christian Koch4
1Neuronal Plasticity Working Group, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany. garcia-forlim@mpib-berlin.mpg.de.
Scientific reports
|October 19, 2024
概括
长时间暴露在超声波 (IS) 中会改变静止状态网络中的大脑连接,影响默认模式,传感器和执行控制网络. 这些变化与体质症状和烦相关,突出了个人对IS的敏感性.
科学领域:
- 神经科学是一个神经科学.
- 环境健康 环境健康
- 心理学 心理学 心理学
背景情况:
- 长时间暴露于超声波 (IS) 的神经效应在很大程度上仍然没有特征.
- 之前关于IS和大脑功能的研究是有限的,只有一个研究检查了功能连接 (FC) 变化.
研究的目的:
- 为了研究长期,无声的超声波暴露对休息状态网络中大脑功能连接 (FC) 的影响.
- 探索超声波灵敏度作为FC变化的预测因素,并检查FC和体质症状之间的相关性.
主要方法:
- 一项为期四周的随机对照试验,38名参与者每晚8小时暴露在6Hz,80-90dB的超声波或假装设备中.
- 在听觉,默认模式 (DMN),传感器 (SMN) 和执行控制 (ECN) 网络中使用静止状态fMRI评估FC变化.
- 分析IS诱导的FC变化,体征症状和自我报告的烦之间的相关性.
主要成果:
- 超声波暴露减少了右前 (DMN) 的FC,并在Vermis IV和V (SMN) 中增加了FC.
- 观察到ECN连接的显著变化,包括右中额头 (BA8) 和右下叶增加的FC.
- 在右下垂体叶的ECN变化与烦有负相关性,而右前皮的DMN变化与体征症状有负相关性.
结论:
- 这项研究提供了第一个证据,证明长时间暴露于超声波会改变DMN,SMN和ECN中的大脑FC,但不会改变听觉网络.
- 对超声波反应的个体差异可能与敏感性,烦和身体症状有关.
- 未来的研究应该专注于灵敏度标志物和详细的症状评估,以了解超声波效应的个体变化.
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