牙周炎与患有高脂血症的人群中全因和特定原因死亡率之间的关联
Jiaying Xu1, Ruya Zhang2, Shanfeng Lin3
1Department of Periodontal and Oral Mucosal Diseases, Wuxi Stomatological Hospital, Wuxi, 214000, P.R. China.
BMC oral health
|October 19, 2024
概括
中度至严重的牙周炎增加了美国成年人患有高脂血症的死亡风险. 这种牙疾病与所有死因,心血管疾病和癌症的死亡风险更高有关.
科学领域:
- 牙周病学和公共卫生
- 心血管健康 心血管健康
- 在瘤学瘤学.
背景情况:
- 超脂血是心血管疾病的重要危险因素.
- 牙周炎是一种慢性炎症性牙疾病,与全身健康问题有关.
- 牙周炎与高脂血症患者的死亡率之间的关联需要进一步研究.
研究的目的:
- 调查牙周炎与全因死亡率之间的关联.
- 检查牙周炎与特定原因死亡率 (包括心血管疾病和癌症) 之间的联系.
- 为了评估这些关联在美国成年人群的高脂血症.
主要方法:
- 利用了跨越多个时期 (1988-1994,1999-2004,2009-2014) 的国家健康和营养检查调查 (NHANES) 的数据.
- 采用考克斯的比例危险和韦布尔的加速失效时间 (AFT) 模型来分析关联.
- 计算的危险比率 (HRs) 和时间比率 (TRs) 使用95%的置信区间 (CI) 来量化风险.
主要成果:
- 在11.83年的随访中,16848名参与者中有4,623人死亡.
- 中度至严重的牙周炎与所有原因死亡率的增加有关 (HR:1.31,P<0.001).
- 发现与心血管疾病相关的死亡率 (HR: 1.36,P=0.001) 和与癌症相关的死亡率 (HR: 1.35,P=0.002) 有显著的关联.
- 观察到剂量与反应的关系,牙周炎的严重程度增加与较高的死亡风险相关 (趋势P<0.001).
结论:
- 中度至严重的牙周炎是美国患有高脂血症的成年人全因死亡率增加的重要危险因素.
- 牙周炎也与心血管疾病和癌症相关死亡率的风险增加有关.
- 这些发现强调了管理高脂血症患者的牙健康的重要性,以减轻死亡风险.
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