杏仁体和腹部海马体对应激诱导的防御行为变化的可分离贡献
Zachary T Pennington1, Alexa R LaBanca1, Patlapa Sompolpong1
1Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Cell reports
|October 20, 2024
概括
压力通过改变大脑电路,影响心理健康. 腹部海马体 (vHC) 和底侧杏仁体 (BLA) 独特地管理压力敏感性和焦虑,揭示了非关联性压力效应的独特神经通路.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 分子精神病学分子精神病学
背景情况:
- 压力显著影响心理健康,已知神经回路用于压力事件的关联记忆.
- 了解非关联性压力影响,如增加压力敏感性和与焦虑相关的行为,需要进一步研究特定的神经回路.
研究的目的:
- 研究腹腔海马体 (vHC) 和底侧杏仁体 (BLA) 在压力后调解非关联性行为变化的不同作用.
- 为了确定压力因素的关联记忆是否影响非关联性压力诱导的行为.
主要方法:
- 在BLA和vHC.中抑制压力诱导的蛋白质合成.
- 在行为评估期间,抑制BLA和vHC的神经元活动.
- 阻断一个压力因素的关联记忆.
主要成果:
- 在BLA中抑制蛋白质合成可以降低压力敏感性,但不能降低焦虑.
- 抑制vHC中的蛋白质合成减少了焦虑,但没有降低压力敏感性.
- 在测试期间,BLA/vHC中的活动抑制证实了它们在防御行为中的可分离作用,独立于关联性压力记忆.
结论:
- 腹部海马体 (vHC) 和底侧杏仁体 (BLA) 在非关联性应激反应中表现出可分离的作用.
- 独特的神经回路和记忆系统是压力对行为长期影响的基础.
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