在热应激 brojlers 中,protocatechuic 酸通过 TLR4/p38 和 NF-κB 途径减轻肠道炎症
Shuaiyong Wang1, Xin Wang1, Yu Gao2
1College of Agriculture and Forestry Science, Linyi University, Linyi, 276000, China.
Poultry science
|October 20, 2024
概括
甲基甲酸 (PCA) 通过改善肠道健康和减少炎症,保护肉免受热应激. 这种天然化合物增强了生长性能和肠道屏障功能,为家禽业提供了潜在的解决方案.
科学领域:
- 动物科学动物科学
- 营养 营养 营养 营养 营养
- 生物化学 生化学
背景情况:
- 热应激对家禽业产生重大影响,影响动物福利和生产力.
- 肠道平衡对于家禽的健康至关重要,但常常受到环境压力因素的影响.
- 源自Eucommia ulmoides Oliver的Protocatechuic酸 (PCA) 以其抗氧化和抗炎性质而闻名.
研究的目的:
- 为了研究PCA对受热应激的肉肠道平衡的保护作用.
- 为了评估PCA对生长性能,阴茎完整性和热应激条件下的炎症反应的影响.
主要方法:
- 肉暴露于热应激,有或没有PCA补充剂.
- 对增长绩效参数进行了监测.
- 对结节组织进行了组织损伤,炎症媒介表达 (TNF-α,IL-6,IL-1β),抗氧化状态 (SOD,T-AOC) 和紧密结节蛋白水平 (ZO-1,Claudin-1,Occludin) 的分析.
- 评估了包括TLR4/p38 MAPK和NF-κB在内的分子通路.
主要成果:
- 补充PCA改善了在热应激期间肉生长性能.
- PCA减轻了关损伤,并降低了促炎细胞因子的表达.
- PCA增强了抗氧化能力,并恢复了超氧化脱酶 (SOD) 和总抗氧化能力 (T-AOC) 的活性.
- 通过增加紧接口蛋白质水平,PCA维持了膜屏障功能.
- PCA抑制了TLR4/p38 MAPK和NF-κB信号通路的激活.
结论:
- PCA有效地保护肉免受热应激引起的肠道损伤.
- 通过调节关键信号通路,PCA可以改善氧化应激和炎症.
- 在热应激条件下,PCA代表了一种有前途的天然补充剂,可以改善家禽的健康和性能.
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