转移体的发展用于库尔库明的局部眼部药物输送
Geisa Nascimento Barbalho1, Stefan Brugger2, Christian Raab3
1Buchanan Ocular Therapeutics Unit, Department of Ophthalmology, Aotearoa-New Zealand National Eye Centre, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1142, New Zealand; Laboratory of Food, Drugs and Cosmetics (LTMAC), University of Brasilia, Brasilia 70910-900, DF, Brazil.
概括
转移体 (TFS) 通过改善透到角膜和结膜来增强局部眼部药物输送. 这项研究证实,TFS是将疏水性药物送入眼睛的有前途平台.
科学领域:
- 眼科药物输送是眼科药物输送.
- 纳米技术在医学中的应用
- 生物医学工程 生物医学工程
背景情况:
- 转移体 (TFS) 是超可变形的弹性双层囊泡,以增强通过皮肤透而闻名.
- 它们对局部眼部药物输送的潜力尚未得到充分探索.
研究的目的:
- 为了评估用于局部眼部药物输送的转基因组.
- 为了比较不同眼睛组织中转移体的增强透性质.
- 评估转移酶体适用于输送水性药物,如黄素.
主要方法:
- 使用Tween 80作为边缘激活剂来配制黄素载荷转基因组.
- 在体外研究中评估了药物释放和前角膜保留.
- 活体研究评估了眼部生物相容性和生物可用性,使用黄素溶液控制.
主要成果:
- 转基因组表现出狭窄的尺寸分布 (<150 nm) 和高的捕获效率 (>99.96%).
- 观察到最小的爆发释放和良好的角膜生物相容性.
- 显著增强的角膜和结膜药物透和更深的药物输送是通过转基因组实现的.
结论:
- 转基因组代表了一个有前途的平台,用于水性药物的眼部输送.
- 这项研究阐明了眼部组织形态和透梯度对药物透的影响.
- 转基因组为眼部治疗提供了更好的生物可用性和治疗效果.
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