探索饮食作为怀孕期间可塑剂的来源,以及对孕妇第二季度代谢健康的影响
Diana C Pacyga1, Luca Jolly2, Jason Whalen3
1Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, USA; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Environmental research
|October 20, 2024
概括
怀孕期间更健康的饮食与较低的孕产妇脂肪率有关. 这一好处可能部分归因于减少了对可塑剂二-2-乙基基甲甲酸盐 (DEHTP) 的暴露.
科学领域:
- 环境健康 环境健康
- 孕产妇健康 孕产妇健康
- 代谢健康 代谢健康
背景情况:
- 孕妇的饮食显著影响怀孕期间的代谢健康.
- 饮食摄入可以导致暴露于代谢干扰物,如酸盐及其替代品.
- 了解饮食,酸盐和母体新陈代谢之间的相互作用至关重要.
研究的目的:
- 调查怀孕期间改善饮食质量是否与较低的甲酸盐和其替代品暴露率有关.
- 确定甲酸盐暴露是否调解了饮食质量与母亲代谢结果之间的关系.
主要方法:
- 在295名孕妇中使用替代健康饮食指数 (AHEI) - 2010评估饮食质量.
- 量化了10个甲酸盐/替代物的19种尿中代谢物.
- 测量了15个血代谢生物标志物,将其缩小到五个主要成分 (PC),代表脂肪,脂质,胆固醇,炎症和生长.
- 使用线性回归和因果调解分析来检查关联.
主要成果:
- 较高的AHEI-2010分数与较低的脂肪PC相关,表明更好的代谢概况.
- 改善的饮食质量与二-2-乙烯基基甲酸盐 (DEHTP) 代谢产物减少18%相关.
- 较低的DEHTP水平部分解释了饮食质量和肥胖PC之间的有益关联 (21%的调解).
结论:
- 饮食质量在怀孕期间对孕产妇脂肪生物标志物产生积极影响.
- 减少对塑化剂DEHTP的暴露可能部分调节更好的饮食的有利影响.
- 研究结果强调了饮食对于减轻食品包装中对内分泌干扰化学物质的暴露的重要性.
相关概念视频
Pathophysiology of Diabetes
874
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
874
Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
Diabetes Mellitus: Type 2 and Gestational
2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
Overview of Carbohydrate Metabolism
762
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
762
Cholesterol: Significance and Regulation
517
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
517
Overview of Lipid Metabolism
1.1K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.1K


