甲状腺刺激激素 (TSH) 调解母亲的金属与儿童神经发育之间的关联:一项前性队列研究
Ling Yu1, Hongling Zhang2, Jiangtao Liu1
1Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
产前暴露于,和与儿童的神经发育延迟有关. 婴儿甲状腺刺激激素 (TSH) 可能会调解这种效应,影响认知和运动发育.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
背景情况:
- 关于金属混合物对儿科神经发育的影响的研究有限.
- 甲状腺刺激激素 (TSH) 在与金属相关的神经发育结果中的潜在调解作用需要进一步调查.
研究的目的:
- 检查对单金属和混合金属产前暴露与儿童神经发育迟缓之间的关联.
- 调查婴儿甲状腺刺激激素 (TSH) 在金属暴露和神经发育迟缓之间的关系中介作用.
主要方法:
- 在2887名孕妇的血中测量金属度.
- 儿童的神经发育在两岁时被评估,使用精神发育指数 (MDIs) 和精神运动发育指数 (PDIs).
- 用了通用线性回归和加权定量总和 (WQS) 回归来分析金属-金属和金属-儿童神经发育关联,并补充了对TSH效应的调解分析.
主要成果:
- 单金属分析表明 (V), (Mn) 和 (Pb) 与神经发育迟缓之间存在积极的关联.
- WQS回归证实了这些发现,V,Mn和Pb被确定为认知延迟的主要贡献者 (OR1.55,95%CI1.23至1.95).
- 调解分析显示,TSH调解金属 (V,Mn,Pb) 与神经发育延迟风险之间的关联,占该效应的3.18%至10.14%.
结论:
- 产前接触特定的金属,特别是V,Mn和Pb,与儿童神经发育迟缓的风险增加有关.
- 婴儿TSH水平在金属暴露和不良神经发育结果之间的途径中发挥着重要的调解作用.
- 这些发现强调了在怀孕期间监测金属暴露的重要性,以及了解儿童神经发育中的内分泌干扰机制.
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