在接受非心血管手术的患者中,炎症状态作为术后风险的预测因素
Syed U Ahmed1, Michael Fisher1, Mohammed S Ahmed1
1Royal Liverpool and Broadgreen University Hospital, NHS Trust, Liverpool, England, United Kingdom.
Annals of vascular surgery
|October 20, 2024
概括
在术后测量细胞间粘附分子-1 (ICAM) 可以帮助识别血管外科手术患者有重大心脏不良事件 (MACE) 风险. 这种炎症生物标志物在经历MACE的患者和没有经历MACE的患者之间显示出显著的差异.
科学领域:
- 心脏病学 心脏病学
- 血管外科 血管外科
- 免疫学 免疫学 免疫学
背景情况:
- 血管外科手术患者在手术后面临重大心脏不良事件 (MACE) 的高风险.
- 炎症机制在术后恢复和MACE发展中发挥作用.
- 现有的风险评分可能无法完全捕捉该人群中的MACE风险.
研究的目的:
- 评估炎症生物标志物在血管外科手术后预测MACE的实用性.
- 调查特定炎症生物标志物与MACE发生之间的相关性.
- 为了确定术后炎症生物标志物水平是否可以识别有风险的患者.
主要方法:
- 75名血管外科手术患者被监测MACE.
- 四个炎症生物标志物 (IL-1,IL-6,ICAM-1,CRP) 在手术前和手术后的1-4天被测量.
- MACE被定义为高水平的热素,心电图变化或中风.
主要成果:
- 细胞间粘附分子-1 (ICAM-1) 在术前和术后水平之间显示出显著的正相关性.
- 在手术后的第一天和第二天,在患有和没有MACE的患者之间,ICAM-1水平显著不同.
- 干白素-1 (IL-1) 也显示出显著的相关性,但只有IL-1和ICAM-1在MACE和非MACE组之间显示出差异.
结论:
- 炎症生物标志物的术后测量,特别是ICAM-1,可以帮助识别患有MACE风险的血管外科患者.
- 炎症生物标志物可以作为现有风险评估工具的辅助.
- 进一步的研究可以完善这些生物标志物的临床实践中的使用.
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