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Updated: Jun 10, 2025

Using Lipid Nanoparticles for the Delivery of Chemically Modified mRNA into Mammalian Cells
10:02

Using Lipid Nanoparticles for the Delivery of Chemically Modified mRNA into Mammalian Cells

Published on: June 10, 2022

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具有稳定结构的工程mRNA可以最大限度地减少双链RNA的形成,并增加蛋白质的表达.

Qianshan Qin1, Huayuan Yan2, Weixiang Gao2

  • 1State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China; Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University), Ministry of Education, Orthopaedic Department of Tongji Hospital, Frontier Science Center for Stem Cell Research, Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China; Suzhou Abogen Biosciences Co., Ltd., Suzhou, Jiangsu 215123, China.

Journal of molecular biology
|October 20, 2024
PubMed
概括

合成信使RNA (mRNA) 疗法面临来自双链RNA (dsRNA) 副产品的挑战. 这项研究确定了预测dsRNA形成的序列特征,从而实现了优化的mRNA设计,以提高疗效和减少免疫反应.

关键词:
有关RNA免疫性的RNA免疫性.净化RNA净化RNA的过程这是一种双链RNA.在体外转录 in vitro转录传递 RNA 的信使 RNA.

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