基于种族/种族的身体脂肪分布与非酒精性脂肪性肝病/纤维化之间的关联
Donghee Kim1, George Cholankeril2, Aijaz Ahmed1
1Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, USA.
Journal of obesity & metabolic syndrome
|October 20, 2024
概括
在所有种族中,内脏脂肪显著增加了非酒精性脂肪性肝病 (NAFLD) 的风险. 根据种族/种族,身体脂肪分布对NAFLD和纤维化有不同的影响,观察到显著的差异.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢综合征是代谢综合征的一种.
- 身体组成分析 身体成分分析
背景情况:
- 身体脂肪分布模式可能会对非酒精性脂肪性肝病 (NAFLD) 和晚期肝纤维化有不同的影响.
- 了解这些种族/种族特异性关联对于有针对性的预防和治疗策略至关重要.
研究的目的:
- 调查身体脂肪分布 (内脏和皮下脂肪) 与NAFLD和显著纤维化的流行率之间的关系.
- 检查这些关联在不同种族/种族群体之间如何变化.
主要方法:
- 这是一项对来自国家健康和营养检查调查 (2017-2018) 的2395名参与者的横截面分析.
- 通过过渡性弹性学评估NAFLD和显著纤维化 (≥F2) 使用控制减弱参数 (CAP) 评分和肝硬度测量 (LSM).
- 使用双能X射线吸收计 (DXA) 量化了内脏和皮下脂肪体积.
主要成果:
- 在一般人群中,增加的内脏脂肪体积与NAFLD (OR,2.05) 和显著纤维化 (OR,1.35) 的更高几率密切相关.
- 非西班牙裔黑人个人表现出与内脏脂肪相关的NAFLD的最高几率 (OR,2.86).
- 皮下脂肪体积也显示出与NAFLD (OR, 1.48) 和显著纤维化 (OR, 2.10) 的显著关联,特别是在与NAFLD相关纤维化 (OR, 2.74) 的西班牙裔中.
结论:
- 内脏脂肪是NAFLD和显著纤维化的主要驱动因素,独立于皮下脂肪.
- 在身体脂肪分布如何影响NAFLD和纤维化发育和进展方面存在显著的种族/民族差异.
更多相关视频
08:41Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
Published on: March 24, 2023
1.1K
07:03Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
792
相关概念视频
01:25Ultrasound II: Endoscopic Ultrasound and FibroScan
80
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
80
01:24Obesity
387
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
387
01:24Overview of Lipid Metabolism
1.1K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.1K