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使用其内源标志物和消化系统疾病患者的遗传变异来表征血vonoprazan和CYP3A活性

Kenta Sakaguchi1, Takafumi Naito2, Kohei Hoshikawa1

  • 1Department of Hospital Pharmacy, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Drug metabolism and pharmacokinetics
|October 20, 2024
PubMed
概括

在患有消化系统疾病的患者中,诺普拉桑的血水平有显著的变化. 由4β-基胆固醇 (4β-OHC) 表示的细胞染色体P450 3A (CYP3A) 活性部分解释了这些变异,这表明它在临床反应中发挥了作用.

关键词:
4β-基胆固醇是一种4β-基胆固醇.在 CYP3A4 中.胃中的脏.药理动力学 药理动力学这就是Vonoprazan.

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