长非编码RNA治疗癌症的进展:向,交付和临床影响
Muhammad Ammad1, Zeeshan Javed2, Haleema Sadia3
1Department of Biotechnology, University of Karachi, Karachi, Pakistan.
Medical oncology (Northwood, London, England)
|October 20, 2024
概括
长非编码RNAs (lncRNAs) 是细胞过程的关键调节者,具有预防癌症的潜力. 本综述探讨了lncRNA生物学,输送系统和针对性治疗的临床试验.
科学领域:
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
- 生物技术是生物技术.
背景情况:
- 长非编码RNAs (lncRNAs) 调节重要的细胞过程,如发育和分化.
- 尽管有潜在的治疗应用,但它们在预防癌症中的作用尚未得到充分探索.
- lncRNAs提供独特的二次结构和序列动机作为新疗法的目标.
研究的目的:
- 审查当前的lncRNA生物学和作用机制.
- 探索纳米配方策略,以提供 lncRNA.
- 检查涉及 lncRNA 传递系统用于疾病治疗的临床试验.
主要方法:
- 关于 lncRNA 研究的文献评论.
- 对lncRNA向策略 (小分子,反意义寡核酸) 的分析.
- 检查药物输送系统和核酸修饰方面的进展.
主要成果:
- lncRNAs与各种人类病理有关.
- 针对 lncRNAs 显示出疾病预防和治疗的前景.
- 在为lncRNA疗法开发特定和有效的输送工具方面,仍然存在挑战.
- 最近的进展提高了药物的稳定性,降低了免疫性,但需要进一步的进展.
结论:
- 基于lncRNA的疗法具有治疗癌症等复杂疾病的巨大潜力.
- 对优化交付系统的进一步研究对于临床翻译至关重要.
- 继续探索 lncRNA 生物学和治疗策略是有必要的.
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