血中S-甲基-5-腺的低含量与术后延迟的神经认知恢复有关
Lei Zhang1,2, Haoli Mao3, Ren Zhou4
1Department of Anesthesiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. weiymzhl@126.com.
Communications biology
|October 20, 2024
概括
手术和麻醉可以导致老年患者的认知能力下降. 较低的S-甲基-5-thioadenosine (MTA) 水平可以预测这种风险,为延迟神经认知恢复 (dNCR) 提供潜在的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 代谢学 代谢学 代谢学
- 老年病的医生 老年病的医生
背景情况:
- 老年人经历了与术后认知障碍相关的代谢物变化.
- 特定代谢物和手术和麻醉后延迟神经认知恢复 (dNCR) 之间的关系尚不清楚.
研究的目的:
- 在老年患者中调查S-甲基-5-腺 (MTA) 和dNCR之间的关联.
- 在麻醉和手术后识别血液代谢物作为dNCR的潜在生物标志物.
主要方法:
- 广泛向的代谢学被用于分析来自小鼠和人类患者的术前和术后血样本.
- 在小鼠大脑中评估了MTA水平和MTA酸化酶活性.
- 在给予MTA后,对小鼠的认知功能和炎症进行了评估.
主要成果:
- 麻醉/手术降低了MTA水平,并在小鼠大脑中激活了MTA酸化酶.
- 在小鼠手术前给予MTA可以预防炎症和认知衰退.
- 患有dNCR的患者手术前血清MTA水平较低.
- 低的手术前和手术后MTA水平与dNCR的风险增加相关.
结论:
- 麻醉和手术可能会通过 metionin 合成途径的改变诱导认知衰退.
- S-甲基-5-腺 (MTA) 显示出作为预测dNCR.的外科手术期生物标志物的潜力.
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