在克罗恩氏病中,临床特征与肉症或肉性肥胖症之间的关联
Takumi Naruse1, Hiroki Sato1, Kazuya Takahashi1
1Division of Gastroenterology & Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Japan.
Internal medicine (Tokyo, Japan)
|October 20, 2024
概括
肉症是一种肌肉损失状况,影响了三分之一的克罗恩病患者. 身体质量指数和疾病活动预测了肉症,有助于在炎症性肠道疾病管理中早期检测.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 临床医学 临床医学
背景情况:
- 克罗恩氏病 (CD) 是一种与营养不良有关的慢性炎症性肠病.
- 标志着骨肌肉损失的萨尔科佩尼亚,损害了身体功能,是营养不良的结果.
- 萨科佩尼性肥胖症 (sarcopenic-o) 是一种严重的萨科佩尼症.
研究的目的:
- 为了研究克罗恩氏病患者的临床特征,这些患者有sarcopenia和sarcopenic-o.
- 开发一种可预测的模型,用于克罗恩氏病患者的缩症.
主要方法:
- 在104名克罗恩病患者的生物电阻分析中评估了身体成分.
- 分析了sarcopenic和sarcopenic-o患者的临床特征.
- 用身体质量指数 (BMI) 和克罗恩病活动指数 (CDAI) 开发了对肉类的预测模型.
主要成果:
- 在33.7%的患者中存在型,而在9.6%的患者中存在型.
- 与对照组相比,sarcopenic患者的骨肌肉指数 (SMI) 和BMI较低,CDAI较高.
- 使用BMI和CDAI进行的萨尔科佩尼亚预测模型显示出高性能 (AUC分别为0.87和0.72).
结论:
- 在克罗恩氏病患者中,sarcopenia和sarcopenic-o是常见的.
- 体重指数和CDAI是有效的临床参数,用于预测CD中的肉症.
- 在CD中,sarcopenic-o可能表明了更严重的肉类的表现.
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