微生物生态系统的变化和血清代谢通过饮食补充与恩拉米辛在断奶小猪的饮食补充
Kana Umemura1, Shiho Miyata1, Guanlin Lyu2
1Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Journal of animal physiology and animal nutrition
|October 21, 2024
概括
恩拉米辛补充剂通过改变肠道细菌和增加促进生长的代谢物,如二甲基甘氨酸,来增强小猪的生长. 这表明在生猪生产中具有作为抗生素替代品的潜力.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
背景情况:
- 抗生素在猪生产中广泛用于促进生长,这引发了人们对抗生素耐药性和环境影响的担忧.
- 研究抗生素促进生长背后的机制对于开发动物农业中更安全的替代品至关重要.
研究的目的:
- 评估恩拉米辛补充剂对小猪生长表现的影响.
- 分析恩拉米对肠道微生物群组成和关键血液代谢物的影响.
- 探索恩拉米辛,肠道细菌,代谢物和肝脏基因表达之间的关系.
主要方法:
- 小猪被补充了恩拉米.
- 用测序技术分析了肠道微生物群的组成.
- 对血液样本进行了代谢分析.
- 量化了与代谢相关的肝脏基因表达.
主要成果:
- 恩拉米辛补充剂促进了小猪的生长,并减少了腹的发生率.
- 观察到肠道微生物组成的显著变化,Limosilactobacillus reuteri的增加.
- 检测到血清二甲基甘氨酸水平升高,这是促进生长的因素.
- 在肝脏中注意到ALDH和二甲基甘氨酸脱酶的mRNA表达增加.
- 在含量中发现了较高度的酸,与L. reuteri丰度和血清二甲基甘氨酸正相关.
结论:
- 恩拉米辛在小猪中促进生长的作用与其对肠道微生物群,血液代谢物和肝脏基因表达的影响有关.
- 这项研究强调了Limosilactobacillus reuteri和二甲基甘氨酸代谢在恩拉米疗效中的作用.
- 研究结果为开发猪生产中抗生素替代策略提供了宝贵的见解.
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