基于纳米结构脂质载体的局部凝作为新型药物输送系统:全面概述
Ujjwal Kumar Biswas1,2, Shreeja Sen1, Susrita Sharma1
1School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha-751003, India.
Current drug delivery
|October 21, 2024
概括
纳米结构脂质载体 (NLCs) 提供了改善的药物输送和稳定性. 本综述涵盖了基于NLC的眼睛,皮肤和皮肤应用的局部凝,详细介绍了它们的开发和评估.
科学领域:
- 制药科学 制药科学
- 纳米技术纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 纳米结构脂质载体 (NLCs) 是纳米载体技术的重大进步.
- 它们的非结构化基质和生物相容的辅助剂提供了增强的药物有效载荷能力和稳定性.
- 通过各种管理途径,NLCs因其在有效药物输送方面的潜力而得到认可.
研究的目的:
- 为提供基于NLC的局部凝用于药物输送提供全面的概述.
- 审查NLCs的分类,制造和表征.
- 讨论基于NLC的局部凝的优点,缺点和评估,用于眼睛,皮肤和透皮途径.
主要方法:
- 对基于NLC的局部凝的文献综述.
- 对NLC分类,生产和表征技术的分析.
- 通过眼部,皮肤和皮肤间传递途径评估药物输送效率.
主要成果:
- 基于NLC的凝对于局部药物输送是有效的.
- 各种NLC配方表现出良好的稳定性和药物负载.
- 报告说,在眼部,皮肤和皮肤透过的药物输送中已有成功的应用.
结论:
- 基于NLC的局部凝是增强药物递送的有希望的平台.
- 它们的可重复制造和生物相容性支持商业可行性.
- 对NLC应用的进一步研究可以优化治疗结果.
相关概念视频
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Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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01:22Drug Delivery: Miscellaneous Routes
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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
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01:18Drug Delivery: Enteral Route
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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